Browsing by Author "Langer, Manuel K"

Now showing items 1-3 of 3

    • Amphipathic barbiturates as marine product mimics with cytolytic and immunogenic effects on head and neck squamous cell carcinoma cell lines 

      von Hofsten, Susannah; Langer, Manuel K; Korelin, Katja; Norvoll Magnussen, Synnøve; Ausbacher, Dominik; Anderssen, Trude; Salo, Tuula; Strøm, Morten B.; Bayer, Annette; Al-Samadi, Ahmed; Berge, gerd (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-30)
      The incidence of head and neck squamous cell carcinoma (HNSCC) is increasing and the conventional treatments for this form of cancer can be tough. Despite the success of existing immunotherapies in some HNSCC patients, many do not respond to this type of treatment. Thus, the development of novel anti-cancer therapies should be prioritized. In the current study, the anticancer activity of a panel ...

    • A concise SAR-analysis of antimicrobial cationic amphipathic barbiturates for an improved activity-toxicity profile 

      Langer, Manuel K; Rahman, Ataur; Dey, Hymonti; Anderssen, Trude; Zilioli, Francesco; Haug, Tor; Blencke, Hans-Matti; Stensvåg, Klara; Strøm, Morten B.; Bayer, Annette (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-05)
      An amphipathic barbiturate mimic of the marine eusynstyelamides is reported as a promising class of antimicrobial agents. We hereby report a detailed analysis of the structure-activity relationship for cationic amphipathic N,N′ -dialkylated-5,5-disubstituted barbiturates. The influence of various cationic groups, hydrocarbon linkers and lipophilic side chains on the compounds’ antimicrobial potency ...

    • Investigation of tetrasubstituted heterocycles reveals hydantoins as a promising scaffold for development of novel antimicrobials with membranolytic properties 

      Langer, Manuel K; Rahman, Ataur; Dey, Hymonti; Anderssen, Trude; Blencke, Hans-Matti; Haug, Tor; Stensvåg, Klara; Strøm, Morten B.; Bayer, Annette (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-24)
      Mimics of antimicrobial peptides (AMPs) have been proposed as a promising class of antimicrobial agents. We report the analysis of five tetrasubstituted, cationic, amphipathic heterocycles as potential AMP mimics. The analysis showed that the heterocyclic scaffold had a strong influence on the haemolytic activity of the compounds, and the hydantoin scaffold was identified as a promising template for ...